Audio by year 2012

Yohan Lee, PhD by AMIA Pharmacoinformatics


31:00 minutes (56.77 MB)

Genome based modeling to reposition drugs for new indications -Podcast by John Poikonen and Yohan Lee

 

Genome biologist Yohan Lee discusses this fasinating breakthrough in drug discovery.  Do not miss this!
 
Yohan Lee discusses the details of these studies and a review.  Issues of drug discovery, genomes, cell tissues, social networks, the 1,000 genome project, how HIEs fit in, EHR data, interoperability, why we need patient participation and more are discussed in this fasinating discussion. 
 
References:
  1. Lussier YA, Chen JL The Emergence of Genome-Based Drug Repositioning; 17 August 2011, Vol 3 Issue 96 96ps35 www.ScienceTranslationalMedicine.org
  2. M. Sirota, J. T. Dudley, J. Kim, A. P. Chiang, A. A. Morgan, A. Sweet-Cordero,  J. Sage,  A.  J. Butte,  Discovery  and preclinical validation of drug indications using compendia  of  public  gene  expression data.  Sci. Transl. Med. 96,96ra77 (2011).
  3. J. T. Dudley, M. Sirota, M. Shenoy, R. Pai, S. Roedder, A. P. Chiang, A. A. Morgan, M. Sarwal, P. J. Pasricha, A. J. Butte, Computational repositioning  of the anticonvulstant topiramate for in? ammatory bowel disease.  Sci. Transl. Med. 96, 96ra76 (2011). 

34:06 minutes (31.22 MB)